Issue link: http://www.epageflip.net/i/518556
ByMarilynnMarchione The Associated Press The first report from a big public-private project to improve genetic test- ing reveals it is not as rock solid as many people be- lieve, with flaws that result in some people wrongly advised to worry about a disease risk and others wrongly told they can relax. Researchers say the study shows the need for con- sumers to be careful about choosing where to have a gene test done and acting on the results, such as hav- ing or forgoing a preventive surgery. "We have very clear doc- umentation that there are differences in what patients are getting" in terms of how tests on the same gene variations are interpreted, said the study leader, Heidi Rehm, genetics lab chief at Brigham and Women's Hos- pital in Boston. When deciding to get tested, either through a doctor's office or by send- ing in a swab to a private company, "patients need to choose labs that are sharing their data" with the broader research community so sci- entists can compare and learn from the results and make testing more accurate for everyone, she said. Dozens of companies now offer gene tests to gauge a person's risk of developing various disorders. One of the newest tests on the mar- ket costs $250 and checks about 20 genes that can af- fect breast cancer risk. But not all gene muta- tions, or variants, are equal. Some raise risk a lot, others just a little, and some not at all. Most are of unknown significance — a quandary for doctors and patients alike. And most variants are uncommon, making it even tougher to figure out which ones matter and how much. To solve these myster- ies and give patients better information, the U.S. gov- ernment several years ago helped form and fund Clin- Var, a database for research- ers around the world to pool gene findings, coded to keep patients' identities confiden- tial. More than 300 labs con- tribute to it, including uni- versities such as Harvard and Emory and some pri- vate companies such as Am- bry Genetics and GeneDX. On Wednesday, the group made its first report at a con- ference in Washington. The study also was published online by the New England Journal of Medicine. So far, the project has tracked more than 172,000 variants in nearly 23,000 genes, a small portion of the millions known to exist but some of the common ones that have been identified. More than 118,000 of these variants have an effect on the risk for a disease — and 11 percent have been an- alyzed by more than one lab so results can be compared. In 17 percent of those cases, labs interpreted the find- ings differently, as either raising the risk of a disease, having no effect on it or hav- ing an unknown effect. At least 415 gene variants now have different inter- pretations that could sway a medical decision, such as whether to have healthy breasts or ovaries removed to lower the risk of cancer, or to get a medical device such as an implanted defi- brillator to cut the risk of sudden cardiac death. "The magnitude of this problem is bigger than most people thought," said Mi- chael Watson, executive di- rector of the American Col- lege of Medical Genetics and Genomics, one of the study's authors. HEALTH Studyrevealsflawsingenetesting;resultso enconflict Washington 90/71 New York 85/66 Miami 87/75 Atlanta 82/67 Detroit 81/60 Houston 86/72 Chicago 83/63 Minneapolis 82/63 Kansas City 78/65 El Paso 93/63 Denver 72/46 Billings 66/49 Los Angeles 77/60 San Francisco 66/54 Seattle 78/56 AIRQUALITYFORECAST Whatitmeans: 0-50:Good; 51-100:Moderate; 101-150:Unhealthyforsensitivepeople; 151+:Unhealthyforall. Source: Airnow.gov City Today'sairquality City Hi/Lo/W Hi/Lo/W CALIFORNIA CITIES National and world forecast s-sunny,pc-partly cloudy,c-cloudy,sh-showers,t-thunderstorms,r-rain,sf-snow flurries,sn-snow,i-ice City Hi/Lo/W Hi/Lo/W Summary National Extremes World Extremes North and South America Asia, Australia Africa CarsonCity Hawthorne Reno Herlong Lovelock Sacramento Yuba City Napa Ukiah Chico Corning Lakeview Alturas Susanville Redding Red Bluff Laytonville Fort Bragg Point Arena Eureka Redway Mount Shasta Yreka Crescent City Ashland Shown is today's weather. Temperatures are today's highs and tonight's lows. Shown are today's noon positions of weather systems and precipitation. Temperature bands are highs for the day. ALMANAC Precipitation Temperatures ALLERGY REPORT Pollenlevels Source: National Allergy Bureau TODAY'S UV INDEX (The higher the number, the faster skin damage will occur.) Extreme Very high High Moderate Low SUN SETTINGS, MOON PHASES Sunrise Sunset Moonrise Moonset Hoursofsunlight River Levels SacramentoRiver Flood 7a.m. 24-hr Stage yest. chg. Lake Levels Elevation Yesterday Storage (acre-feet) Percent Capacity Q: A: FRIDAY 95° 64° SATURDAY 92° 64° Pa rtly sunn y and ho t Pa rtly sunn y and ho t SUNDAY 89° 61° Some sun, t hen clouds and warm MONDAY 83° 59° Pe riods of clouds and sunshine TODAY 92° 63° Sunny to partly cloudy and hot. Mainly clear tonight. High ....................................................................... 84° Low ........................................................................ 58° Normal high ......................................................... 84° Normal low ........................................................... 57° Record high ........................................... 102° in 1984 Record low .............................................. 42° in 1953 Humidity noon today ........................................ 34% 24 hours through 2 p.m. yesterday ................. 0.00" Month to date ................................................... 0.30" Normal month to date ..................................... 1.09" Season to date ................................................ 19.97" Normal season to date .................................. 23.91" Red Bluff through 2 p.m. yesterday Chico .................................................................. Good Napa ................................................................... Good Red Bluff .............................................. Not available Redding ............................................... Not available Yuba City ............................................. Not available Allergy, dust and dander today: Beneficial Grass ............. Moderate Mold .........................Low Trees ....................... Low Weeds ..................... Low 8 Highest at 12 p.m. Today 5:44 a.m. 8:29 p.m. 3:47 p.m. 2:59 a.m. Friday 5:43 a.m. 8:30 p.m. 4:44 p.m. 3:29 a.m. 14 hr., 45 min. Jun2 Full Jun9 Last New Jun16 First Jun24 aboveBendBridge......................27 ...........2.70 .......none atHamiltonCity.........................148 ......129.31 ....... -0.10 atOrdFerry................................114 ........96.84 ....... -0.08 atRedBluffDiversionDam.......253 ......238.70 .......none atTehamaBridge ......................213 ......201.40 .......none atVinaWoodsonBridge............183 ......167.25 ....... -0.03 BlackButte ....................455.67..............69,720 .....48.5% LakeOroville..................739.74.........1,583,754 .....42.4% LakeShasta ...................981.56.........2,446,595 .....53.7% LakeTrinity..................2259.51.........1,039,546 .....39.3% Whiskeytown...............1209.07............238,119 .....98.8% Weather Trivia ™ What is the apparent temperature? A heat index that factors together the temperature and humidity. Today Friday Anaheim 78/59/pc 82/60/pc Bakersfield 92/65/s 96/68/s Chula Vista 70/59/pc 72/59/pc Crescent City 58/50/pc 58/50/s Death Valley 105/71/s 107/73/s Eureka 58/50/pc 58/50/pc Fremont 68/55/pc 70/55/pc Fresno 92/62/s 96/65/s Glendale 79/60/pc 82/62/pc Huntington Beach 69/59/pc 72/60/pc Irvine 70/61/pc 73/62/pc Lake Tahoe 73/40/s 76/42/s Long Beach 77/61/pc 80/62/pc Los Angeles 77/60/pc 79/61/pc Mammoth Mountain 74/43/s 76/45/s Modesto 89/57/s 93/59/s Monterey 62/52/pc 64/52/pc Moreno Valley 85/55/pc 90/58/s Napa 73/51/pc 74/51/pc Needles 100/75/s 103/76/s Oakland 65/53/pc 66/54/pc Oxnard 70/57/pc 71/58/pc Redding 95/64/s 97/68/pc Riverside 86/56/pc 92/59/s Sacramento 86/56/s 88/57/s San Bernardino 86/56/pc 91/59/s San Diego 70/62/pc 72/62/pc San Francisco 66/54/pc 67/54/pc San Jose 75/54/pc 77/55/pc San Luis Obispo 75/51/pc 75/53/pc Santa Ana 73/61/pc 76/62/pc Santa Barbara 70/54/pc 72/56/pc Santa Clarita 81/59/pc 85/62/s Stockton 86/54/s 91/56/s Ventura 69/57/pc 70/58/pc Yosemite Valley 85/53/pc 89/54/s Today Friday Albuquerque 84/57/s 84/59/pc Atlanta 82/67/t 84/66/t Baltimore 89/65/t 86/65/pc Boston 79/60/t 70/57/pc Buffalo 75/56/pc 84/65/pc Chicago 83/63/s 80/58/t Cincinnati 82/64/pc 84/66/t Dallas 84/68/t 79/66/t Denver 72/46/c 62/47/t Detroit 81/60/s 85/66/t El Paso 93/63/s 96/65/pc Fargo 79/52/t 61/38/c Honolulu 83/69/c 83/70/sh Houston 86/72/pc 84/71/t Indianapolis 83/65/s 84/65/pc Kansas City 78/65/t 77/59/t Las Vegas 95/72/s 97/72/s Louisville 85/68/pc 85/69/pc Miami 87/75/pc 88/76/pc Minneapolis 82/63/t 70/48/r New Orleans 86/73/pc 87/73/t New York City 85/66/t 81/64/pc Oklahoma City 80/66/t 80/63/t As a weak push of cool air settles over the lower Great Lakes today, a zone of showers and thunderstorms will extend from northern New England to the mid-Atlantic and the Ohio Valley. Warm and humid conditions will hold in the South and in the coastal Northeast. A mosaic of show- ers and storms will occur over the Plains to the Gulf Coast, due to a southerly flow of humid air. Another round of showers and thunderstorms will affect the central and northern Rockies. Any of the storms across the nation can become locally severe during the afternoon hours. High ........................... 100° in Presidio, TX Low .............................. 32° in Truckee, CA High ........... 118° in Nawabshah, Pakistan Low ... -16° in Summit Station, Greenland Bogota 67/50/t 64/50/t Buenos Aires 64/54/s 62/54/pc Caracas 86/74/t 86/74/t Ensenada 76/56/pc 73/58/pc Mexico City 75/55/t 75/57/t Montreal 72/51/sh 80/64/pc Rio de Janeiro 85/71/t 78/68/r Tijuana 72/59/pc 73/60/pc Toronto 79/55/s 79/63/pc Vancouver 71/55/s 71/53/s Orlando 88/69/pc 88/72/t Philadelphia 88/68/pc 85/67/pc Phoenix 98/73/s 102/75/s Pittsburgh 81/62/pc 83/65/t Portland, ME 80/57/t 73/53/pc Portland, OR 83/58/s 83/57/pc St. Louis 86/70/t 83/69/t Salt Lake City 69/51/t 74/55/pc Seattle 78/56/s 77/53/pc Tucson 96/65/s 98/67/s Washington, DC 90/71/t 86/71/pc Cairo 94/68/pc 85/67/s Casablanca 82/61/t 80/61/s Johannesburg 72/47/s 73/49/s Kinshasa 92/72/t 90/72/t Lagos 87/75/t 87/75/t Nairobi 78/60/t 78/61/pc Tripoli 78/58/s 82/62/s Baghdad 106/85/pc 103/79/pc Beijing 90/70/pc 77/60/sh Hong Kong 89/82/c 90/81/t Jerusalem 91/59/pc 79/53/s Kabul 83/54/t 76/54/t Manila 92/80/sh 92/80/t Melbourne 63/49/sh 59/46/pc New Delhi 111/83/pc 111/84/pc Seoul 84/59/pc 84/63/pc Singapore 90/80/t 90/79/t Sydney 72/57/pc 72/52/pc Tehran 92/73/c 94/75/pc Tokyo 82/66/pc 81/68/sh Amsterdam 59/49/sh 60/47/r Athens 72/62/t 72/61/sh Belgrade 64/46/pc 71/49/s Berlin 68/49/pc 67/51/pc Budapest 66/45/pc 73/51/pc Dublin 55/41/c 55/40/sh London 62/47/c 61/46/sh Madrid 87/60/s 84/59/t Moscow 77/58/t 73/60/t Paris 70/50/pc 65/50/pc Rome 75/54/s 75/55/s Stockholm 61/46/c 59/47/sh Vienna 65/48/pc 74/56/pc Zurich 69/49/pc 72/52/t 80/49 84/53 83/56 81/54 81/49 86/56 89/58 73/51 87/54 88/63 90/63 77/43 78/44 81/52 95/64 92/63 86/56 64/52 69/51 58/50 78/53 83/50 86/51 58/50 83/52 Forecasts and graphics provided by AccuWeather, Inc. ©2015 Saturday,June13,2015 CLASSICCARSHOW·RIBCOOK-OFF·LIVEMUSIC CarShowstarts@9:00am·RibCook-Offstarts@11:00am Tickets just $20 each, available at coat check or online at www.rollinghillscasino.com GOLF•LODGING•EVENTCENTER GAMING • DINING • EQUESTRIAN I-5ATLIBERALAVE • CORNING WWW.ROLLINGHILLSCASINO.COM (530) 529-1220 100 Jackson St.,Red Bluff 2 FREE Tanning Sessions withanynew membership in the month of May Valid'tillMay31,2015 RUNNINGS ROOFING SheetMetalRoofing ResidentialCommercial • Composition • Shingle • Single Ply Membrane Ownerisonsiteoneveryjob ServingTehamaCounty 530-527-5789 530-209-5367 NoMoney Down! 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