Issue link: https://www.epageflip.net/i/276076
By Lindsey Tanner The Associated Press CHICAGO » These days, it's faster and cheaper than ever to decipher a person's entire DNA. But a small study suggests that looking for disease risks that way may not be ready for the masses. For one thing, the re - search found that gene vari- ants most likely linked with significant disease were the least likely to be accurately identified. And analyzing the mass of data from the DNA scan is a daunting task, research - ers said. Some experts think more targeted gene-mapping is a better approach. But while whole genome sequencing is mostly done for research, it has far-reaching potential for diagnosing and treating genetic diseases, even in people with no known risks. The new results show its promise and its challenges. Stanford University re - searchers performed whole genome sequencing in 12 healthy people. Most of the millions of genetic variants they found were of uncer- tain significance, although one woman was found to have a high genetic risk for cancer. DNA is recovered by a simple blood test and deci - phered by machines. The difficulty lies in inter- preting the findings and fig- uring out which variants are important and which ones can be ignored. That takes days of sophisticated fol - low-up lab tests and inter- pretation to reveal poten- tially meaningful genetic information, the research- ers said. Dr. Euan Ashley, a senior co-author and Stanford as- sociate professor of medi- cine and genetics, likened the technology to "an unruly teenager who has grown up very fast. There's huge po - tential." "This paper is like paren- tal tough love — we have to be really honest about where we are in order to bring it up to clinical stan- dards," he said. For the test, they used two commercially available instruments to sequence the DNA — the second one to validate the initial find - ings. But less than one-third of variants in inherited dis- ease genes were confirmed. Several specialists in- cluding medical geneticists, genetic counselors and a pa- thologist examined the find- ings and recommended fol- low-up tests. Medical intervention was considered appropriate for one participant, a woman with no family history of breast or ovarian cancer found to have a genetic vari - ant strongly linked with those diseases. That find- ing led to surgery to remove her ovaries and increased breast cancer screening. The cost per patient was about $17,000 plus hundreds of dollars in follow-up tests. Some centers charge less and the cost is expected to drop considerably as the technique is improved. SCIenCe Gene mapping study shows promise, challenges Washington 70/28 New York 57/23 Miami 84/66 Atlanta 66/29 Detroit 28/3 Houston 63/41 Chicago 24/8 Minneapolis 20/16 Kansas City 43/31 El Paso 59/39 Denver 48/26 Billings 54/32 Los Angeles 81/55 San Francisco 69/47 Seattle 57/39 AIR QUALITY FORECAST What it means: 0-50: Good; 51-100: Moderate; 101-150: Unhealthy for sensitive people; 151+: Unhealthy for all. Source: Airnow.gov City Today's air quality City Hi/Lo/W Hi/Lo/W CALIFORNIA CITIES National and world forecast Weather(W): s-sunny, pc-partly cloudy, c-cloudy, sh-showers, t-thunderstorms, r-rain, sf-snow flurries, sn-snow, i-ice City Hi/Lo/W Hi/Lo/W Summary National Extremes World Extremes North and South America Asia, Australia Europe Africa Carson City Hawthorne Reno Herlong Lovelock Sacramento Yuba City Napa Ukiah Chico Corning Lakeview Alturas Susanville Redding Red Bluff Laytonville Fort Bragg Point Arena Eureka Redway Mount Shasta Yreka Crescent City Ashland Shown is today's weather. Temperatures are today's highs and tonight's lows. Shown are today's noon positions of weather systems and precipitation. Temperature bands are highs for the day. ALMANAC Precipitation Temperatures ALLERGY REPORT Pollen levels Source: National Allergy Bureau TODAY'S UV INDEX (The higher the number, the faster skin damage will occur.) 11+: Extreme 8-10: Very high 6-7: High 3-5: Moderate 0-2: Low SUN SETTINGS, MOON PHASES Sunrise Sunset Moonrise Moonset Hours of sunlight River Levels Sacramento River Flood 7 a.m. 24-hr Stage yest. chg. Lake Levels Elevation Yesterday Storage (acre-feet) Percent Capacity Q: A: THURSDAY 76° 42° FRIDAY 76° 44° Pa rtly sunn y and wa rm Pa rtly sunn y SATURDAY 80° 44° Ve ry wa rm with sunshine SUNDAY 79° 46° Ve ry wa rm with plenty of sun TODAY 75° 37° Plenty of sunshine. Mainly clear tonight. High ....................................................................... 74° Low ........................................................................ 48° Normal high ......................................................... 64° Normal low ........................................................... 43° Record high ............................................. 86° in 2007 Record low .............................................. 30° in 2006 Humidity noon today ........................................ 22% 24 hours through 2 p.m. yesterday ................. 0.00" Month to date ................................................... 1.85" Normal month to date ..................................... 1.47" Season to date ................................................ 10.18" Normal season to date .................................. 19.53" Red Bluff through 2 p.m. yesterday Chico .................................................................. Good Napa ................................................................... Good Red Bluff .............................................. Not available Redding ............................................... Not available Yuba City ........................................................... Good Allergy, dust and dander today: Neutral Grass ....................... Low Mold ......................... Low Trees ............. Moderate Weeds ................ Absent 5 Highest at 1 p.m. Today 7:26 a.m. 7:12 p.m. 3:49 p.m. 5:01 a.m. Thursday 7:24 a.m. 7:13 p.m. 4:45 p.m. 5:35 a.m. 11 hr., 46 min. Mar 16 Full Mar 23 Last New Mar 30 First Apr 7 at Bend Bridge 27 3.90 -2.70 at Hamilton City 148 133.40 +3.50 at Ord Ferry 114 102.90 +5.30 at Red Bluff Diversion Dam 253 239.60 +0.40 at Tehama Bridge 213 203.10 +0.40 Lake Shasta...................956.19 1,980,915 43.5% Lake Trinity .................2281.63 1,256,524 47.5% Weather Trivia ™ What was the greatest reported snowfall from the blizzard of 1888? 58 inches at Saratoga, N.Y. Today Thursday Anaheim 82/55/s 80/51/s Bakersfield 77/47/s 72/46/s Chula Vista 75/51/s 73/52/s Crescent City 56/40/s 55/43/pc Death Valley 81/59/pc 83/49/pc Eureka 57/37/s 55/40/pc Fremont 72/44/s 69/45/pc Fresno 72/46/s 74/48/s Glendale 84/52/s 80/49/s Huntington Beach 72/55/s 70/54/s Irvine 81/56/s 77/52/s Lake Tahoe 48/15/s 55/22/s Long Beach 82/50/s 78/53/s Los Angeles 81/55/s 79/55/s Mammoth Mountain 49/23/pc 57/15/s Modesto 72/42/s 74/42/s Monterey 69/46/s 64/44/s Moreno Valley 74/49/s 75/43/s Napa 70/43/s 70/38/pc Needles 76/53/pc 78/51/pc Oakland 69/43/s 65/45/pc Oxnard 78/49/s 74/49/s Redding 74/44/s 76/45/pc Riverside 78/40/s 79/39/s Sacramento 71/38/s 72/39/pc San Bernardino 75/51/s 79/44/s San Diego 76/54/s 73/55/s San Francisco 69/47/s 64/46/pc San Jose 75/44/s 73/44/s San Luis Obispo 79/42/s 77/44/s Santa Ana 81/56/s 75/52/s Santa Barbara 77/42/s 75/44/s Santa Clarita 80/49/s 79/50/s Stockton 71/37/s 73/38/s Ventura 78/49/s 75/49/s Yosemite Valley 63/33/pc 67/31/s Today Thursday Albuquerque 53/34/pc 58/37/pc Atlanta 66/29/t 51/33/s Baltimore 72/26/t 33/20/pc Boston 44/22/r 26/13/sn Buffalo 28/4/sn 15/10/pc Chicago 24/8/sf 34/28/pc Cincinnati 45/11/r 30/28/s Dallas 61/37/s 65/47/s Denver 48/26/pc 59/29/s Detroit 28/3/sn 20/19/pc El Paso 59/39/s 68/46/s Fargo 29/20/sn 43/24/pc Honolulu 82/69/pc 83/69/pc Houston 63/41/s 63/43/s Indianapolis 37/9/sn 33/32/s Kansas City 43/31/s 61/41/s Las Vegas 68/52/pc 70/50/pc Louisville 50/17/r 39/34/s Miami 84/66/pc 76/59/s Minneapolis 20/16/pc 42/29/pc New Orleans 68/44/pc 59/45/s New York City 57/23/r 28/20/sn Oklahoma City 58/33/s 66/41/s A strong storm will impact many areas east of the Mississippi River today. Over 6 inches of snow is expected from the southern Great Lakes to New England, which will create widespread travel problems. Rain will bring the risk for some flooding across the mid-Atlantic. Thunderstorms, some strong with damaging winds, will affect lo- cations from southeastern Pennsylvania to North Carolina. It will be blustery and quite cold across the Midwest. Gusty Santa Ana winds will bring an increased threat for wildfires across parts of Southern California. High ............................... 91° in Dryden, TX Low ......................... 14° in Lewistown, MT High ................................ 108° in San, Mali Low ... -47° in Summit Station, Greenland Bogota 64/49/t 64/49/t Buenos Aires 81/64/s 79/66/s Caracas 89/73/s 90/73/s Ensenada 73/51/pc 73/52/s Mexico City 80/50/s 76/49/pc Montreal 24/9/sn 19/5/sn Rio de Janeiro 91/76/pc 87/76/t Tijuana 72/51/pc 73/51/s Toronto 29/6/sn 16/12/pc Vancouver 51/40/s 51/42/c Orlando 83/50/t 66/45/s Philadelphia 68/24/r 29/20/sn Phoenix 78/56/pc 76/53/pc Pittsburgh 44/8/r 20/16/pc Portland, ME 40/22/sn 23/3/sn Portland, OR 62/37/s 59/43/pc St. Louis 42/24/sn 56/39/s Salt Lake City 50/31/pc 55/35/s Seattle 57/39/s 55/42/c Tucson 76/50/s 74/47/s Washington, DC 70/28/t 32/24/pc Cairo 66/52/sh 65/52/pc Casablanca 66/45/c 66/43/pc Johannesburg 75/56/t 70/55/r Kinshasa 87/72/pc 91/72/pc Lagos 91/76/t 91/77/t Nairobi 86/59/pc 85/60/pc Tripoli 69/53/pc 69/52/pc Baghdad 67/48/r 68/52/s Beijing 52/34/pc 55/41/pc Hong Kong 75/67/pc 76/63/c Jerusalem 53/43/sh 51/41/sh Kabul 56/33/pc 60/38/c Manila 90/75/s 91/76/s Melbourne 69/54/pc 74/55/c New Delhi 79/57/t 82/57/pc Seoul 53/34/r 52/30/pc Singapore 90/75/c 91/79/pc Sydney 86/68/t 81/65/r Tehran 57/46/r 54/42/sh Tokyo 63/52/pc 59/39/r Amsterdam 59/39/s 58/39/s Athens 61/47/pc 59/45/pc Belgrade 58/33/s 58/35/s Berlin 57/38/s 61/38/s Budapest 59/34/s 56/34/s Dublin 55/37/s 58/42/s London 59/37/pc 61/41/pc Madrid 63/39/pc 59/39/pc Moscow 40/33/pc 46/35/pc Paris 63/41/s 64/43/pc Rome 61/44/s 63/46/s Stockholm 50/34/pc 50/36/s Vienna 58/37/s 60/39/s Zurich 58/32/s 61/35/s 56/28 55/34 57/26 59/29 57/20 71/38 73/41 70/43 73/33 73/43 75/44 55/21 58/17 59/30 74/44 75/37 71/33 61/43 63/45 57/37 72/39 64/28 65/24 56/40 67/31 Forecasts and graphics provided by AccuWeather, Inc. ©2014 Saigon Bistro NEW BUFFET Lunch Express American & International Food Lunch Buffet Wed-Sat 11 - 2:30 DINNER BUFFET Fri-Sat 5pm-8pm Biscuits & Gravy, Meatloaf, Salad Bar, Sushi, Gumbo, Cajun Shrimp, Sandwiches, Fruit Salad and more Wine & Beer - Catering available 723 Walnut St. Red Bluff • 528-9670 900 Jackson St. • 527-1833 Lic. #0530362 Home Auto Farm Commercial www.andy4ins.com ANDY HOUGHTON Insurance Agency Motorcycle Boat RV Life Smog Check (MOST CARS & PICK-UPS) 527-9841 • 195 S. 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