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ByStevePeoplesand Jonathan Lemire TheAssociatedPress MIAMI Withtheturbulent White House race scram- bled in new directions, Don- ald Trump is campaigning like it all hinges on one all- too-familiar swing state: Florida. There was late action Wednesday in such unlikely arenas as Arizona and Mich- igan, too — and in North Carolina, where President Barack Obama tried to en- ergize black support for Hillary Clinton. But Trump marched ahead in his third multi-day visit to the Sun- shine State in recent weeks. The Republican nomi- nee lashed out at "Crooked Hillary" in Miami, predict- ing that a Clinton victory would trigger an "unprece- dented and protracted con- stitutional crisis" as fed- eral investigators probe the former secretary of state's email practices. Conceding nothing in the state, Clinton has also been a frequent visitor. She posedforpicturesandshook handsduringasurprisevisit to a South Florida Carib- bean-American neighbor- hood Wednesday morning. Both sides agree the New York businessman has vir- tually no chance to win the presidency without Florida's trove of 29 electoral votes. Clinton has been ahead there in opinion polls, but Democrats acknowledge thattheFBI'srenewedatten- tion to her has helped rally reluctant Republicans be- hind their nominee. That's given Trump an enthusiasm boost in Florida and across Midwestern battlegrounds long considered reliably blue territory. "I'm definitely nervous," said former Pennsylvania Gov. Ed Rendell, a Demo- crat. "Democrats in Michi- gan, Wisconsin and Penn- sylvania, if you heard it was over, if you thought those states were in the bag, don't believe it." PerhapsheedingRendell's warning, Clinton's team is devoting new resources to states like Michigan, which hasn't supported a Republi- can presidential nominee in nearly three decades. While she had two ap- pearancesWednesdayinRe- publican-leaning Arizona, Clinton planned to spend part of Friday in Detroit. At the same time, a pro-Clin- ton super PAC was spend- ing more than $1 million on Michigan airwaves along with at least $1 million more in Colorado, another state where Clinton has enjoyed a significant polling advan- tage for much of the fall. Early voting numbers in some states suggest that her challenge stems, at least in part, from underwhelming support from African-Amer- ican voters. Weak minority support could complicate her path in other states, too, including North Carolina, Pennsylvania and Michigan. Obama, the nation's first black president, headlined a rally with singer-songwriter James Taylor in North Caro- lina on Wednesday, the first of two visits he's planned this week. Early voting in North Carolina shows a 5 percentage point drop in ballots from black voters from 2012. "I know there are a lot of people in barber shops, in beauty salons, in the neigh- borhoods who are saying to themselves, you know, we love Barack, we especially love Michelle, so it was ex- citing, and now we're not ex- cited so much," Obama said on the "Tom Joyner Morn- ing Show." "I need everybody to un- derstand that everything we've done is dependent on me being able to pass the baton to somebody who be- lieves in the same things I believe in." CAMPAIGN 2016 Trump campaigning in stretch like it all depends on Florida EVANVUCCI—THEASSOCIATEDPRESS Donald Trump speaks during a campaign rally Wednesday in Miami. By Marilynn Marchione The Associated Press Doctors have found a dis- turbing downside to some powerful new drugs that harness the immune sys- tem to fight cancer: In rare cases, they may cause po- tentially fatal heart dam- age, especially when used together. "The problem is, no one has this on their radar," so patients are not routinely checked for it, said Dr. Javid Moslehi, head of a Vander- bilt University clinic spe- cializing in heart risks from cancer therapies. He led a report Wednes- day in the New England Journal of Medicine de- scribing two patients who died of heart trouble two weeks after receiving their first doses of two Bristol- Myers Squibb drugs, Opdivo and Yervoy, for the deadly skin cancer melanoma. Two similar drugs also are on the market, and the study leaders believe they might pose heart risks, too. "My sense is that this is a class effect, not limited to one drug," Moslehi said. The risks do not negate the huge benefits of these relatively new types of drugs, doctors stress. Called checkpoint inhibitors, they have transformed treatment of several types of cancer by helping the immune system see and attack tumors. In rare cases, the immune system seems to attack not only the tumor but also the heart and other muscles, causing dangerous inflam- mation and heart rhythm problems. Patients need to be told of the risks, moni- tored closely and treated quickly with medicines to quell the immune response if trouble develops. Besides melanoma, the Opdivo-Yervoy combination is used to treat some lung cancers, though at different doses. Other checkpoint in- hibitors include Genentech's Tecentriq, for bladder can- cer, and Merck & Co.'s Key- truda, which former Presi- dent Jimmy Carter received for melanoma that spread to his brain. Many more are in testing. There have been occa- sional, previous reports of heart troubles with these drugs. After the two recent deaths, doctors asked Bris- tol-Myers to check patient safety records on Opdivo and Yervoy. As of April, 18 cases of serious heart inflammation were found among 20,594 patients receiving either or both drugs, a rate of 0.09 percent. It was more severe and more common among people on both drugs, affect- ing 0.27 percent of those pa- tients. Bristol-Myers scien- tists helped write the jour- nal report, and some other authors consult for the com- pany. MEDICINE Some immune-boosting cancer drugs may pose rare heart risks 25yearsprofessional experience. QualityWork Very Reasonable Rates Red Bluff Transmission • Automatic • Manual • Computer Diagnosis • Clutches • Transfer Cases • CV Axles CALL TODAY! 529-4493 440 Antelope Blvd. #6 Bob's Youcantmissus... Weonly moved 50 feet!! Through a Child's Eyes… AspecialcontestbringingTehamaCounty school children and local businesses together … to the delight of Daily News readers! 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